Wednesday, April 28, 2010
Nothing like...
Tuesday, April 27, 2010
Version 2
Monday, April 26, 2010
Eigen-What V. 2.0
Saturday, April 24, 2010
"Oregonians prove that stress and lack of sleep and early death are linked... in flies"
“BIOLOGICAL CLOCK” COULD BE A KEY TO BETTER HEALTH, LONGER LIFE
3-1-10
CORVALLIS, Ore. – If you aren’t getting a good, consistent and regular night’s sleep, a new study suggests it could reduce your ability to handle oxidative stress, cause impacts to your health, increase motor and neurological deterioration, speed aging and ultimately cut short your life.
That is, if your “biological clock” genes work the same way as those of a fruit fly. And they probably do.
In research just published in the journal Aging, scientists from Oregon State University outline for the first time how a key gene that helps control circadian rhythms can improve the health of aging fruit flies if it is intact, but can result in significant health impacts, up to and including earlier death, if it is absent.
Of particular interest, the research found, was that young fruit flies without this gene were able to handle some stress, but middle-aged and older flies were not.
“We’re beginning to identify some of the underlying mechanisms that may help explain why organisms age,” said Natraj Krishnan, a research associate in the OSU Department of Zoology. “This study suggests that young individuals may be able to handle certain stresses, but the same insults at an older age cause genetic damage and appear to lead to health problems and earlier death. And it’s linked to biological clocks.”
It’s not completely clear how closely the effects of genetic damage in fruit flies correlate to humans and other animals, Krishnan said, but “the genes themselves, their molecular mechanisms and function is essentially the same, conserved through many millions of years of evolution.” The “period” gene in fruit flies, for instance, is also found and expressed in almost every cell in the human body.
This research examined that gene, which is one of four primary genes that help control the biological clock in many animals – the rhythms that are related to the cycle of day and night, and can be disrupted by anything from inadequate sleep to jet lag or working the swing shift. The study used some normal fruit flies and other mutant flies in which the “period” gene was absent.
The work was done under the leadership of Jadwiga Giebultowicz, an OSU professor of zoology, in collaboration with Dr. Doris Kretzschmar from the Oregon Health and Sciences University. The research was supported by the National Institutes of Health and the Oregon Partnership for Alzheimer’s Research.
In control studies, the mutant flies with no functional “period” gene lived just about as long as normal flies, unless they were stressed. In experiments, researchers caused a mild metabolic stress – an elevated level of reactive oxygen species for 24 hours – to the flies at various times, which corresponded to their youth, middle age and old age. There was no significant change in the young flies. But in middle-age and older flies, significant damage began to occur.
Mutant flies lost some of their motor ability to climb, and morphologic examinations of their brains showed higher levels of neuronal degeneration, similar to neurodegenerative diseases such as Alzheimer’s disease in humans. When exposed to a single stressful event in “middle age,” the mutant flies had a 12 percent shorter lifespan than normal flies exposed to the same stress. And when exposed to a single stress in old age, their lifespan was 20 percent shorter.
The study concluded that expression of the “period” gene naturally declines with age. If the same is true for humans, that could help explain why people may lose some of their ability to handle oxidative and other stresses at a time of their life when they need it most.
The scientists theorized that the “period” gene is regulating pathways involved in removal of oxidative damage, and those without this function experienced the symptoms of aging more quickly. This could ultimately have impacts on everything from neurological damage to heart disease and cancer.
“What’s worth noting, of course, is that every animal species, unless they are in a protected laboratory, experiences stressful events,” Krishnan said. “That’s part of a normal life. The metabolic challenge we presented to these fruit flies was only a moderate stress. But even so, it appeared to later cause motor and neuronal degeneration and an earlier death in the mutant flies, due to faster buildup of cellular damage.”
Further research will explore ways in which biological clocks might be “re-vitalized.”
“Understanding these mechanisms will help to determine in the future whether strong circadian clocks add water to the fountain of youth,” the researchers wrote in their conclusion.
About the OSU College of Science: As one of the largest academic units at OSU, the College of Science has 14 departments and programs, 13 pre-professional programs, and provides the basic science courses essential to the education of every OSU student. Its faculty are international leaders in scientific research.
Last night
Thursday, April 22, 2010
Looking good for apartment in Corvallis
Wednesday, April 21, 2010
It's time to get it right and...
The hardwoods.
Tuesday, April 20, 2010
"how to fix your macbook charger"

blarg.
Thursday, April 15, 2010
Found it!
Tuesday, April 13, 2010
Free internet?
Tree Physiology FTW!
Consistent with OPT, total root mass as a proportion of whole-plant mass generally was greater in low vs. high N. However, changes in root mass were influenced by TNC mass in all seven species and were especially strong in the three oak species. In contrast, non-storage mass contributed to increased total root mass under low N in three of the seven species. Root morphology also responded, with higher fine-root surface area (normalized to root mass) under low vs. high N in four species. Although biomass partitioning responses to resources were consistent with OPT, our results challenge file implicit assumption that increases in root mass Under low nutrient levels primarily reflect allocation shifts to build more root surface area. Rather. root responses to low N included increases in: TNC, non-storage mass and fine-root surface area, with increases in TNC being the largest and most consistent of these responses. The greatest TNC accumulation occurred when C was abundant relative to N. Total nonstructural carbohydrates storage could provide seedlings a carbon buffer when respiratory or growth demands are not synchronized with photosynthesis, flexibility in responding to uncertain and fluctuating abiotic and biotic conditions, and increased access to soil resources by providing an energy source for mycorrhizae, decomposers in the rhizosphere, or root uptake of nutrients.
Ever watched a Canadian goose honk?
Monday, April 12, 2010
Perhaps the one, single, only reason why I will ever think the Twitter is good
Sunday, April 11, 2010
a raw beet!
Saturday, April 10, 2010
Interesting Book I Read Yesterday
Friday, April 09, 2010
Things that are good
Thursday, April 08, 2010
Ridiculous
On the verge
http://www.ex-parrot.com/pete/upside-down-ternet.html
If I could program and someone was stealing my wifi I would totally do this to them
Wednesday, April 07, 2010
Everyone's favorite arachnid!
Natural Areas
Tuesday, April 06, 2010
Effective advertising campaigns
"Make _________ Yours."
KRISTIN APPROVES.
My first Disapproval!

Monday, April 05, 2010
Whew
Sunday, April 04, 2010
Beds!


I learned a new skill today!
The sugar content of dried fruits and over ripe fruits is markedly higher than the sugar content in "straight off the vine fruits." I would guess this is because the drupe is preparing to be released from the plant and needs to best emphasize its means of survival by being eaten by an animal and scarified or just having lots of accessible glucose for the cotelydon to grow. In any case, why not just skip that step and work from raisins? There is obviously such thing as "prune juice"-- I would think raisins, perhaps processed in a food processor, could be "juiced" with other raisins floating within a cheesecloth. Starting with a more concentrated liquid would probably work well. I will maybe experiment with this-- it would be curious to see if it actually increased the sweetness of the process... if it works, who knows, a new consumer product? :)
Saturday, April 03, 2010
Images from my computer

And this... is also an image from my thesis defense presentation for monday. If I don't pass, Kaan is going to come over from NWN land and drop the some mad blue monk on the committee. He's serious too, man, don't mess with him. I mean, he's blue. Did anyone ever mess with Paul Bunyan's blue Ox, Babe? Or with Zoolander when he was Blue Steel? Of course not. You don't mess with blue.
Fail- a nonparametric distribution?
I’m doin me
I’m livin’ life right now, maybe"